反応 #71898

反応方程式

ethyl cis(±)-2-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-4-methyl-1,3-oxazole-5-carboxylate

Ethyl cis(±)-2-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-4-methyl-1,3-oxazole-5-carboxylate

ethyl acetate

→

title compound

収率 100.8%

Ethyl cis(±)-2-(4-amino-3-methoxypiperidin-1-yl)-4-methyl-1,3-oxazole-5-carboxylate

収率 100.8%

溶媒

methanol

反応条件

実験手順

The same operation as in Example (95b) was performed using ethyl cis(±)-2-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-4-methyl-1,3-oxazole-5-carboxylate obtained in Example (107a) (0.32 g, 0.77 mmol), 10% Pd/C (0.3 g), ethyl acetate (3 mL) and methanol (3 mL), to obtain 0.22 g of the title compound as a brown oily substance (100%).

出典