反応 #71896

反応方程式

butyl cis(±)-2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl)-5-methyl-1,3-oxazole-4-carboxylate

lithium hydroxide

methanol

→

title compound

収率 99.0%

cis(±)-2-(4-{[(4-Chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl)-5-methyl-1,3-oxazole-4-carboxylic acid

収率 99.0%

溶媒

THF

反応条件

実験手順

The same operation as in Example (91d) was performed using butyl cis(±)-2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl)-5-methyl-1,3-oxazole-4-carboxylate obtained in Example (106d) (0.32 g, 0.69 mmol), 2 N lithium hydroxide (3 mL, 6 mmol), methanol (2 mL) and THF (5 mL), to obtain 0.28 g of the title compound as a colorless solid (99%).

出典