反応 #71796

反応方程式

Example ( 1g )

tert-Butyl cis(±)-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidine-1-carboxylate

hydrochloric acid ethyl acetate

1,1′-thiocarbonyldiimidazole

→

title compound

cis(±)-4-Chloro-5-ethyl-N-[1-(1H-imidazol-1-ylthiocarbonyl)-3-methoxypiperidin-4-yl]-1H-imidazole-2-carboxamide

溶媒

methanol

反応条件

後処理

1. 1
   濃縮The reaction solution was concentrated under reduced pressure

実験手順

tert-Butyl cis(±)-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidine-1-carboxylate obtained by the method described in Example (1g) (130 mg, 0.34 mmol) was dissolved in methanol (1 mL). A 4 N hydrochloric acid/ethyl acetate solution (3 mL) was added, and the mixture was stirred for 15 minutes. The reaction solution was concentrated under reduced pressure, and then the same operation as in Example (64a) was performed using 1,1′-thiocarbonyldiimidazole (81 mg, 0.45 mmol), to obtain the title compound. The resulting compound was used for the next reaction without purification.

出典