反応 #717763

反応方程式

sodium cyclopentadienide

benzyl(p-chlorophenyl)ketone

magnesium chloride

→

6-benzyl-6-(p-chlorophenyl)fulvene

溶媒

THF

THF

THF

反応条件

後処理

1. 1
   温度Then, the product was heated
2. 2
   温度refluxed for an hour
3. 3
   温度the obtained pink slurry was cooled in an ice bath
4. 4
   workup.ADDITIONwas subsequently added
5. 5
   workup.STIRRINGThen, the product was stirred at room temperature for 18 hours
6. 6
   その他the obtained orange solution was quenched with dilute aqueous hydrochloric acid
7. 7
   workup.ADDITIONThen, 30 mL of diethyl ether was added
8. 8
   抽出the soluble part in diethyl ether was extracted
9. 9
   洗浄washed with an aqueous solution of saturated sodium hydrogen carbonate, water
10. 10
    workup.DISTILLATIONThe solvent was distilled off
11. 11
    その他the residue was subsequently purified by silica gel column chromatography
12. 12
    その他to obtain an objective that

実験手順

Under a nitrogen atmosphere, 2.45 g (25.7 mmol) of anhydrous magnesium chloride and 20 mL of dry THF were put into a 100-mL Schlenk flask and then stirred. To this mixed solution, 10.6 mL (21.2 mmol) of a solution of sodium cyclopentadienide having a concentration of 2.0 mol/L in THF was added. Then, the product was heated and refluxed for an hour, the obtained pink slurry was cooled in an ice bath, and a solution in which 3.5 g (17.8 mmol) of benzyl(p-chlorophenyl)ketone had been dissolved in 15 mL of dry THF was subsequently added thereto. Then, the product was stirred at room temperature for 18 hours, and the obtained orange solution was quenched with dilute aqueous hydrochloric acid. Then, 30 mL of diethyl ether was added thereto, the soluble part in diethyl ether was extracted, and the organic phase was neutralized and washed with an aqueous solution of saturated sodium hydrogen carbonate, water, and a saturated salt solution and then dehydrated with anhydrous magnesium sulfate. The solvent was distilled off, the residue was subsequently purified by silica gel column chromatography to obtain an objective that was a reddish orange solid (amount: 2.7 g), and the objective was directly used in the subsequent process.

出典