反応 #71558

反応方程式

4-nitrophenol

triethylamine

ethyl acetate

water

→

butyl 4-nitrophenyl carbonate

溶媒

tetrahydrofuran

butyl chloroformate

反応条件

後処理

1. 1
   温度under cooling on ice
2. 2
   その他The organic layer was separated
3. 3
   洗浄washed with a saturated sodium chloride aqueous solution
4. 4
   乾燥dried over anhydrous magnesium sulfate
5. 5
   その他After removing the solvent
6. 6
   その他by evaporation under reduced pressure

実験手順

Into a solution of 3.00 g of 4-nitrophenol and 3.31 mL of triethylamine in 30 mL of tetrahydrofuran, 2.75 mL of butyl chloroformate was dropped under cooling on ice. To the reaction mixture, after stirred at the same temperature for 10 min, ethyl acetate and water were added. The organic layer was separated, washed with a saturated sodium chloride aqueous solution, and dried over anhydrous magnesium sulfate. After removing the solvent by evaporation under reduced pressure, 4.60 g of butyl 4-nitrophenyl carbonate was obtained as a light yellow oily matter.

出典