反応 #71478

反応方程式

5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid

5-[4-(4-methoxy-benzyl)-piperazin-1-ylmethyl]-pyridin-2-ylamine

→

Title compound

5-(2,6-Dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid {5-[4-(4-methoxy-benzyl)-piperazin-1-ylmethyl]-pyridin-2-yl}-amide

溶媒

DCM MeOH

反応条件

後処理

1. 1
   その他The title compound was prepared in analogy to the procedure

実験手順

The title compound was prepared in analogy to the procedure described in Step 14.1 but using 5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid (Step 159.1), 5-[4-(4-methoxy-benzyl)-piperazin-1-ylmethyl]-pyridin-2-ylamine (Step 105.1) and stirring the reaction mixture for 20 h at rt. Title compound: ESI-MS: 672.0 [M+H]+; TLC: Rf=0.25 (DCM/MeOH, 9:1).

出典