反応 #71464

反応方程式

dimethyl-(2-nitro-1H-imidazol-4-ylmethyl)-amine

8-(2-chloro-6-fluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester

MeOH THF

MeOH

→

title compound

8-(2-Chloro-6-fluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (4-dimethylaminomethyl-1H-imidazol-2-yl)-amide

溶媒

DCM MeOH

反応条件

後処理

1. 1
   その他The title compound was prepared in analogy to the procedures

実験手順

The title compound was prepared in analogy to the procedures described in Example 14 but using 8-(2-chloro-6-fluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester (Step 144.1), Raney nickel and MeOH/THF (1:1) instead of palladium on carbon and MeOH in Step 14.2, and dimethyl-(2-nitro-1H-imidazol-4-ylmethyl)-amine (Step 22.1) instead of 2-nitroimidazole in Step 14.3. The title compound: ESI-MS: 485.1 [M+H]+; tR=3.24 min (System 1); TLC: Rf=0.20 (DCM/MeOH/NH3aq, 91.5:7.5:1).

出典