反応 #71356

反応方程式

4-(4-methylpiperazin-1-yl)-aniline

8-naphthalen-1-yl-quinoxaline-5-carboxylic acid

1-naphtylboronic acid

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Title compound

8-Naphthalen-1-yl-quinoxaline-5-carboxylic acid [4-(4-methyl-piperazin-1-yl)-phenyl]-amide

溶媒

DCM MeOH

反応条件

後処理

1. 1
   その他The title compound was prepared in analogy to the procedure
2. 2
   その他The latter compound was synthesized

実験手順

The title compound was prepared in analogy to the procedure described in in Step 14.1 but stirring the reaction mixture overnight and using 4-(4-methylpiperazin-1-yl)-aniline (WO2006000420) and 8-naphthalen-1-yl-quinoxaline-5-carboxylic acid. The latter compound was synthesized as described in Steps 1.2-1.7 but using 1-naphtylboronic acid in Step 1.4. Title compound: ESI-MS: 474.0 [M+H]+; tR=4.34 min (System 1); TLC: Rf=0.45 (DCM/MeOH/NH3aq, 94:5:1).

出典