反応 #71260

反応方程式

(R)-5-bromo-2,3-dihydro-1H-inden-2-amine((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate

DBU

propane-2-sulfonyl chloride

→

(R)—N-(5-bromo-2,3-dihydro-1H-inden-2-yl)propane-2-sulfonamide

収率 87.0%

溶媒

DCM

DCM

HCl

反応条件

後処理

1. 1
   その他The mixture was purged with nitrogen
2. 2
   その他to come to room temperature
3. 3
   workup.ADDITIONthe phases mixed
4. 4
   その他separated
5. 5
   抽出The aqueous phase was further extracted with DCM (2×100 mL)
6. 6
   洗浄before combined organics were washed with brine
7. 7
   濃縮Concentration
8. 8
   その他gave a light yellow oil which
9. 9
   その他was purified on silica eluting with 75% DCM/heptane
10. 10
    その他Desired fractions were collected
11. 11
    濃縮concentrated

実験手順

(R)-5-bromo-2,3-dihydro-1H-inden-2-amine((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate (7.88 mmol, 3.5 g) was suspended in DCM (40 mL) and DBU (23.63 mmol, 3.53 mL, 3.60 g) was added. The mixture was purged with nitrogen and cooled in an ice bath before dropwise addition of propane-2-sulfonyl chloride (15.75 mmol, 1.760 mL, 2.246 g). Stirring was continued at 0° C. for 1 h before allowing to come to room temperature. The mixture was diluted with DCM (100 mL) and 1N HCl (100 mL) and the phases mixed and separated. The aqueous phase was further extracted with DCM (2×100 mL) before combined organics were washed with brine. Concentration gave a light yellow oil which was purified on silica eluting with 75% DCM/heptane then neat DCM. Desired fractions were collected and concentrated to give (R)—N-(5-bromo-2,3-dihydro-1H-inden-2-yl)propane-2-sulfonamide as a colourless oil (2.18 g, 87%). 1H NMR (400 MHz, CDCl3) δ 1.39 (d, 6H) 2.88 (m, 2H) 3.17 (sept, 1H) 3.28 (m, 2H) 4.27 (m, 2H) 7.08 (d, 1H) 7.30 (d, 1H) 7.35 (s, 1H)

出典