反応 #71055

反応方程式

Water

N2

4-(2-methyl-[1,3]dioxolan-2-yl)-pyridine-2-carbaldehyde

NaBH4

→

title compound

[4-(2-Methyl-[1,3]dioxolan-2-yl)-pyridin-2-yl]-methanol

溶媒

MeOH

反応条件

後処理

1. 1
   抽出the mixture extracted with EA (3×30 mL)
2. 2
   乾燥extracts were dried over Na2SO4
3. 3
   ろ過filtered
4. 4
   その他the solvents were removed under reduced pressure

実験手順

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), 4-(2-methyl-[1,3]dioxolan-2-yl)-pyridine-2-carbaldehyde (1100 mg, 5.69 mmol) was dissolved in MeOH (15 mL). NaBH4 (278 mg, 7.05 mmol) was added portionwise at 0° C. and the reaction mixture was stirred at rt for 1 h. Water was added and the mixture extracted with EA (3×30 mL). The combined org. extracts were dried over Na2SO4, filtered, and the solvents were removed under reduced pressure to give the title compound as a yellow oil. LC-MS-conditions 02: tR=0.41 min; [M+H]+=196.51.

出典