反応 #710504

反応方程式

5-phenyl-1,3,4-thiadiazol-2-amine

K2CO3

chloroacetyl chloride

→

compound C3

収率 76.0%

2-chloro-N-(5-phenyl-1,3,4-thiadiazol-2-yl)acetamide

収率 76.0%

溶媒

DMF

反応条件

後処理

1. 1
   workup.STIRRINGstirred
2. 2
   ろ過filtered
3. 3
   洗浄The resulting solid was washed with water
4. 4
   その他dried in the oven under vacuum

実験手順

To a mixture of 5-phenyl-1,3,4-thiadiazol-2-amine (C1, 1.06 g, 6 mmol) and K2CO3 (0.83 g, 6 mmol) in anhydrous DMF (20 mL), was added chloroacetyl chloride (C2, 0.48 mL, 6 mmol). The mixture was stirred at room temperature for 4 h. The reaction mixture was then poured into ice-water (100 mL), stirred, and then filtered. The resulting solid was washed with water, and then dried in the oven under vacuum to afford compound C3 (1.15 g, 76%) as a white solid.

出典