反応 #710503

ord-09beeee2505841458329c4dc2d85ed28

反応方程式

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
O=C([O-])O.[Na+]
sodium bicarbonate
→
O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Na+].[Na+].[Na+]
Sodium Citrate Citric Acid

反応物

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
O=C([O-])O.[Na+]
sodium bicarbonate

試薬

なし

溶媒

O
water
O
water

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他reaction
  2. 2
    その他for the reaction
  3. 3
    その他Carbon dioxide is evaporated rapidly
  4. 4
    その他water is gradually evaporated
  5. 5
    workup.ADDITIONa mixture of 87% Sodium citrate and 13% citric acid active ingredient
  6. 6
    その他The product is then dried
  7. 7
    その他crushed to fine particles
  8. 8
    その他to produce an active composition suitable for formulation into the pharmacological formulations of this invention

実験手順

Mix one part citric acid and one part sodium bicarbonate than gradually spray sterile water into the mixture to make reaction. The water is merely the medium for the reaction. Carbon dioxide is evaporated rapidly and water is gradually evaporated. The remaining product is a mixture of 87% Sodium citrate and 13% citric acid active ingredient. The product is in the form of crystals. The product is then dried and crushed to fine particles to produce an active composition suitable for formulation into the pharmacological formulations of this invention.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US09301935B2uspto-grants-2016_04