反応 #710482

反応方程式

2-chloro-5-chloromethyl pyridine

2-aminopyridine

→

1-[(6-chloropyridin-3-yl)methyl]pyridin-2(1H)-imine hydrochloride

収率 86.9%

溶媒

DMF

反応条件

後処理

1. 1
   workup.DISTILLATIONDMF was distilled off under reduced pressure, acetonitrile
2. 2
   workup.ADDITIONwas added
3. 3
   その他to precipitate a solid
4. 4
   その他the solid was collected
5. 5
   洗浄washed well with acetonitrile
6. 6
   その他dried

実験手順

3.00 g (18.6 mmol) of 2-chloro-5-chloromethyl pyridine was dissolved in 20 ml of anhydrous DMF, 1.75 g (18.6 mmol) of 2-aminopyridine was added thereto, and the resulting mixture was stirred at 80° C. for 8 hours and at room temperature for 5 hours. After the reaction was completed, DMF was distilled off under reduced pressure, acetonitrile was added thereto to precipitate a solid, and the solid was collected, washed well with acetonitrile and then dried to obtain 2.07 g (yield 44%) of 1-[(6-chloropyridin-3-yl)methyl]pyridin-2(1H)-imine hydrochloride.

出典