反応 #710470

反応方程式

2-bromo-5-methylpyridine

N-bromosuccinimide

→

2-bromo-5-bromomethylpyridine

収率 20.0%

溶媒

carbon tetrachloride

反応条件

後処理

1. 1
   温度the resulting mixture was heated
2. 2
   温度refluxed for 19 hours
3. 3
   その他was returned to room temperature
4. 4
   濃縮concentrated under reduced pressure
5. 5
   その他purified by silica gel column chromatography (hexane:ethyl acetate=19:1)

実験手順

500 mg (2.92 mmol) of 2-bromo-5-methylpyridine was dissolved in 15 ml of carbon tetrachloride, 623 mg (3.50 mmol) of N-bromosuccinimide and 10 mg of benzoyl peroxide were added thereto, and the resulting mixture was heated and refluxed for 19 hours. After the reaction was completed, the reaction solution was returned to room temperature, concentrated under reduced pressure and purified by silica gel column chromatography (hexane:ethyl acetate=19:1) to obtain 143 mg (yield 20%) of 2-bromo-5-bromomethylpyridine.

出典