反応 #710467

反応方程式

2-chloro-3-fluoro-5-methyl pyridine

N-bromosuccinimide

→

5-(bromomethyl)-2-chloro-3-fluoropyridine

収率 51.0%

溶媒

carbon tetrachloride

反応条件

後処理

1. 1
   温度the resulting mixture was heated
2. 2
   温度refluxed overnight
3. 3
   その他was returned to room temperature
4. 4
   濃縮concentrated under reduced pressure
5. 5
   その他purified by silica gel column chromatography (hexane:ethyl acetate=19:1)

実験手順

4.00 g (27.6 mmol) of 2-chloro-3-fluoro-5-methyl pyridine was dissolved in 80 ml of carbon tetrachloride, 7.37 g (41.4 mmol) of N-bromosuccinimide and 20 mg of benzoyl peroxide were added thereto, and the resulting mixture was heated and refluxed overnight. After the reaction was completed, the reaction solution was returned to room temperature, concentrated under reduced pressure and purified by silica gel column chromatography (hexane:ethyl acetate=19:1) to obtain 3.06 g (yield 51%) of 5-(bromomethyl)-2-chloro-3-fluoropyridine.

出典