反応 #710093

反応方程式

1-bromo-4-chloro-3,3,4-trimethyl-2-pentanone

potassium hydroxide

water

→

2,2,3,3-tetramethylcyclopropane-1-carboxylic acid

溶媒

1,4-dioxane

dioxane

反応条件

後処理

1. 1
   その他to obtain

実験手順

A solution of 4.1 g of 1-bromo-4-chloro-3,3,4-trimethyl-2-pentanone in 10 ml of 1,4-dioxane was added dropwise at 30° C to a solution comprising 3.3 g of potassium hydroxide, 30 ml of water and 20 ml of dioxane, and the resulting solution was stirred at 20° C for 15 hours. Thereafter, the reaction solution was worked up in the same manner as in Example 1 to obtain 1.8 g of the desired 2,2,3,3-tetramethylcyclopropane-1-carboxylic acid as a white crystal (yield, 76%).

出典