反応 #710092

反応方程式

3,3,4-trimethyl-4-chloro-2-pentanone

bromine

→

1-bromo-4-chloro-3,3,4-trimethyl-2-pentanone

溶媒

methanol

反応条件

後処理

1. 1
   抽出extracted twice with dichloromethane
2. 2
   乾燥The dichloromethane layer was dried over anhydrous magnesium sulfate
3. 3
   濃縮concentrated

実験手順

2.2 Grams of 3,3,4-trimethyl-4-chloro-2-pentanone was dissolved in 15 ml of methanol, and 2.50 g (1.2 times by mole) of bromine was added dropwise at 20° C. After stirring for 1 hour, the reaction solution was poured into ice water and extracted twice with dichloromethane. The dichloromethane layer was dried over anhydrous magnesium sulfate and concentrated to obtain 3.1 g of the desired 1-bromo-4-chloro-3,3,4-trimethyl-2-pentanone (a halogeno-ketone compound of the foregoing formula (II) wherein a substituent X is a bromine atom) (yield, 96%).

出典