反応 #70944

反応方程式

2-(trifluoromethyl)pyridine-3-carbothioamide

1-[3,4-bis(benzyloxy)-5-nitrophenyl]-2-bromoethanone

→

4-(3,4-bis(benzyloxy)-5-nitrophenyl)-2-(2-(trifluoromethyl)pyridin-3-yl)thiazole

溶媒

ethanol

反応条件

後処理

1. 1
   workup.ADDITIONthe reaction mixture was poured onto water (50 mL)
2. 2
   ろ過The resulting precipitate was filtered off
3. 3
   洗浄washed with water (25 mL)
4. 4
   その他dried
5. 5
   その他Recrystallisation from dichloromethane/isopropanol

実験手順

A mixture of 2-(trifluoromethyl)pyridine-3-carbothioamide (0.227 g, 1.10 mmol) and 1-[3,4-bis(benzyloxy)-5-nitrophenyl]-2-bromoethanone (0.50 g, 1.10 mmol) were refluxed overnight in absolute ethanol (5 mL). After cooling to room temperature, the reaction mixture was poured onto water (50 mL). The resulting precipitate was filtered off, washed with water (25 mL) and dried. Recrystallisation from dichloromethane/isopropanol afforded 4-(3,4-bis(benzyloxy)-5-nitrophenyl)-2-(2-(trifluoromethyl)pyridin-3-yl)thiazole, 0.539 g (87%).

出典