反応 #7093

反応方程式

1,5-diiodopentane

oxindole

n-butyllithium

ammonium chloride

N,N,N′,N′-tetramethylethylenediamine

→

subtitled compound

収率 69.6%

Spiro[cyclohexane-1,3′-[3H]indol]-2′-(1′H)one

収率 69.6%

溶媒

tetrahydrofuran

EtOAc

反応条件

後処理

1. 1
   workup.ADDITIONwere added
2. 2
   その他After 15 min. the layers were separated
3. 3
   抽出the aqueous phase was extracted EtOAc (×2)
4. 4
   抽出The combined organic layers were extracted with hydrochloric acid (1N)
5. 5
   洗浄washed with brine (500 cm3)
6. 6
   乾燥dried (MgSO4)
7. 7
   濃縮concentrated
8. 8
   その他to obtain an oil
9. 9
   その他The oil was triturated with hexane (200 cm3) and benzene (20 cm3)
10. 10
    その他The precipitate was collected
11. 11
    その他dried in vacuo

実験手順

A solution of oxindole (25 g, 0.19 mol) in anhydrous tetrahydrofuran (800 cm3) was cooled to −20° C., then n-butyllithium (2.5M in hexanes, 152 cm3, 0.38 mol) was added slowly followed by N,N,N′,N′-tetramethylethylenediamine (51 cm3, 0.38 mol,). After 15 min. 1,5-diiodopentane (174 g, 0.54 mol) was added slowly and the mixture was allowed to warm to room temperature. After stirring for 16 h. saturated aqueous ammonium chloride solution (1 L) and EtOAc (1 L) were added. After 15 min. the layers were separated and the aqueous phase was extracted EtOAc (×2). The combined organic layers were extracted with hydrochloric acid (1N), then washed with brine (500 cm3), dried (MgSO4), and concentrated to obtain an oil. The oil was triturated with hexane (200 cm3) and benzene (20 cm3). The precipitate was collected and dried in vacuo to obtain the subtitled compound (26.3 g, 69.6%) as colorless crystals: mp 110–114° C.; 1H NMR (DMSO-d6) δ 1.67 (m, 10H), 6.84 (d, 1H, J=8 Hz) 6.94 (t, 1H, J=8 Hz), 7.17 (t, 1H, J=8 Hz), 7.44 (d, 1H, J=8 Hz), 10.3 (s, 1H).

出典