反応 #70920

反応方程式

hydrochloric acid

aluminium chloride

3-methoxy-5-nitro-3′-(6-(trifluoromethyl)pyridin-2-yl)biphenyl-4-ol

pyridine

→

5-nitro-3′-(6-(trifluoromethyl)pyridin-2-yl)biphenyl-3,4-diol

溶媒

1,2-dichloroethane

反応条件

後処理

1. 1
   温度cooled to room temperature
2. 2
   ろ過The precipitate was filtered off
3. 3
   洗浄washed with water
4. 4
   その他dried

実験手順

To a stirred solution of 3-methoxy-5-nitro-3′-(6-(trifluoromethyl)pyridin-2-yl)biphenyl-4-ol (0.288 g, 0.738 mmol) in 1,2-dichloroethane (10 mL) cooled in an ice-water bath was added aluminium chloride (0.123 g, 0.922 mmol) in one portion followed by pyridine 0.233 g, 2.95 mmol) dropwise. The resulting red suspension was stirred at 80° C. for two hours, then cooled to room temperature and poured onto cold 2 N aqueous hydrochloric acid (100 mL). The precipitate was filtered off, washed with water and dried to give 5-nitro-3′-(6-(trifluoromethyl)pyridin-2-yl)biphenyl-3,4-diol, 0.164 g, (59%).

出典