反応 #70915

反応方程式

water

1-(3,4-dimethoxy-5-nitro-phenyl)-3-dimethylamino-propen-1-one

2-(trifluoromethyl)nicotinimidamide

potassium tert-butoxide

→

4-(3,4-dimethoxy-5-nitrophenyl)-2-(2-(trifluoromethyl)pyridin-3-yl)pyrimidine

溶媒

ethanol

反応条件

後処理

1. 1
   温度to cool to room temperature
2. 2
   ろ過the resulting precipitate was filtered off
3. 3
   洗浄washed with water
4. 4
   その他dried

実験手順

A stirred suspension of 1-(3,4-dimethoxy-5-nitro-phenyl)-3-dimethylamino-propen-1-one (0.28 g, 1.0 mmol), 2-(trifluoromethyl)nicotinimidamide (0.283 g, 1.5 mmol) and potassium tert-butoxide (0.17 g, 1.5 mmol) in absolute ethanol (5 mL) was heated to 80° C. in a sealed tube for one hour and then allowed to cool to room temperature. The mixture was poured onto cold water (100 mL) and the resulting precipitate was filtered off, washed with water and dried to give 4-(3,4-dimethoxy-5-nitrophenyl)-2-(2-(trifluoromethyl)pyridin-3-yl)pyrimidine, 0.296 g (73%).

出典