反応 #70835

反応方程式

6-chloronicotinic acid

SOCl2

→

desired product

収率 93.0%

6-Chloronicotinoyl chloride hydrochloride

収率 93.0%

反応条件

後処理

1. 1
   温度to reflux for 2 h
2. 2
   その他The SOCl2 was evaporated to dryness

実験手順

A solution of 6-chloronicotinic acid (10.00 g, 63.5 mmol) in SOCl2 (37 mL) was heated to reflux for 2 h. The SOCl2 was evaporated to dryness, to afford 12.56 g of the desired product (yield: 93%).

出典