反応 #707008

反応方程式

2.3-dichloro-pyridine

toluene

Bromophenol

sodium hydroxide

→

title compound

4-(3-Chloropyridin-2-yloxy)bromobenzene

溶媒

ethyl acetate

water

反応条件

後処理

1. 1
   温度cooled
2. 2
   その他The organic layer is separated
3. 3
   洗浄washed with dilute NaOH and saturated NaCl
4. 4
   乾燥dried (MgSO4)
5. 5
   濃縮concentrated

実験手順

Bromophenol (3.74 g, 22 mmol) is stirred with 50% sodium hydroxide solution (16 mL) for about 1 hour then treated with hexadecyltributylphosphonium bromide (3.25 g, 6.4 mmol), 2.3-dichloro-pyridine (3.2 g, 21.6 mmol) and toluene (15 mL). The mixture is heated to 100° C. for 18 hours, cooled and diluted with ethyl acetate and water. The organic layer is separated, washed with dilute NaOH and saturated NaCl, dried (MgSO4) and concentrated. Flash chromatography (5% EtOAc/hexanes) yielded the title compound (4.4 g, 15 mmol).

出典