反応 #70641

ord-3d5058b4f7644799a83183f49e5ee90b

反応方程式

O=S(=O)(Cl)c1cc(Br)cc(C(F)(F)F)c1
3-bromo-5-(trifluoromethyl)benzene-1-sulfonyl chloride
CC(C)(C)NS(=O)(=O)c1cc(CN)ccc1F
5-aminomethyl-N-tert-butyl-2-fluoro-benzenesulfonamide
→
CC(C)(C)NS(=O)(=O)c1cc(CN)cc(C(F)(F)F)c1
3-Aminomethyl-N-tert-butyl-5-trifluoromethyl-benzenesulfonamide

反応物

O=S(=O)(Cl)c1cc(Br)cc(C(F)(F)F)c1
3-bromo-5-(trifluoromethyl)benzene-1-sulfonyl chloride
CC(C)(C)NS(=O)(=O)c1cc(CN)ccc1F
5-aminomethyl-N-tert-butyl-2-fluoro-benzenesulfonamide

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

3-Aminomethyl-N-tert-butyl-5-trifluoromethyl-benzenesulfonamide was synthesized in a manner analogous to 5-aminomethyl-N-tert-butyl-2-fluoro-benzenesulfonamide in Example 3, using 3-bromo-5-(trifluoromethyl)benzene-1-sulfonyl chloride in place of 5-chloro-2-fluorobenzene-1-sulfonyl chloride.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08536187B2uspto-grants-2013_09