反応 #70635

反応方程式

3-amino-6-chloropicolinamide

potassium carbonate

4-fluorophenylboronic acid

→

3-amino-6-(4-fluorophenyl)picolinamide

収率 92.0%

溶媒

DMF

water

反応条件

後処理

1. 1
   その他Solvents were removed
2. 2
   workup.ADDITION1N HCl (30 ml) was added to the mixture
3. 3
   ろ過The resulting solid was filtered

実験手順

A mixture of 3-amino-6-chloropicolinamide (2 g), potassium carbonate (3.2 g), tetrakis(triphenylphosphine) palladium (0.674 g) and 4-fluorophenylboronic acid (1.79 g) in DMF (50 mL) and water (10 mL) was heated to 120° C. for 16 hours. Solvents were removed and 1N HCl (30 ml) was added to the mixture. The resulting solid was filtered to provide 2.48 g of 3-amino-6-(4-fluorophenyl)picolinamide which was characterized by its mass spectrum as follows: MS (m/z) 232 [M+H]+.

出典