反応 #706328

反応方程式

allyl bromide

ethyl salicylate

K2CO3

→

ethyl 2-(2-propenyloxy)benzoate

収率 98.3%

溶媒

DMF

反応条件

後処理

1. 1
   温度The reaction mixture was then heated on a steam bath for 2 hours
2. 2
   その他the K2CO3 was removed by filtration
3. 3
   workup.ADDITIONthe reaction mixture was poured into water
4. 4
   抽出extracted with ethyl acetate (3×300 ml)
5. 5
   洗浄The organic layer was washed with brine
6. 6
   乾燥dried over MgSO4
7. 7
   その他the solvent was removed

実験手順

To a solution of ethyl salicylate (100 g, 0.602 mol) in DMF (400 ml) was added K2CO3 (150 g), followed by the dropwise addition of allyl bromide (87.5 g, 0.723 mol). The reaction mixture was then heated on a steam bath for 2 hours, the K2CO3 was removed by filtration and the reaction mixture was poured into water and extracted with ethyl acetate (3×300 ml). The organic layer was washed with brine, and dried over MgSO4, and the solvent was removed to afford 122 g (98%) of ethyl 2-(2-propenyloxy)benzoate.

出典