反応 #70621

反応方程式

3-bromo-5-(trifluoromethyl)benzene-1-sulfonyl chloride

4-Aminomethyl-N-tert-butyl-3-methyl-benzenesulfonamide

NMP

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3-Aminomethyl-N-tert-butyl-5-trifluoromethyl-benzenesulfonamide

反応条件

実験手順

3-Aminomethyl-N-tert-butyl-5-trifluoromethyl-benzenesulfonamide was synthesized in a manner analogous to 4-Aminomethyl-N-tert-butyl-3-methyl-benzenesulfonamide in Example 4, using 3-bromo-5-(trifluoromethyl)benzene-1-sulfonyl chloride in place of 4-bromo-3-methylbenzene-1-sulfonyl chloride. In the second step NMP was used as the solvent, Pd(dppf)Cl2 alone was used as catalyst and the reaction mixture was stirred at 150° C. for 30 min.

出典