反応 #70538

反応方程式

solution

1-(2-chloroimidazo[1,2-a]pyridin-3-yl)ethanone

1,1-di-tert-butoxy-N,N-dimethylmethanamine

→

title compound

(E)-1-(2-chloroimidazo[1,2-a]pyridin-3-yl)-3-(dimethylamino)prop-2-en-1-one

溶媒

N-methyl-2-pyrrolidinone

反応条件

後処理

1. 1
   濃縮The reaction was concentrated under high vacuum on a rotavap at 60° C
2. 2
   その他The residual solid was triturated with 5 mL ether
3. 3
   ろ過filtered
4. 4
   その他dried

実験手順

In a 100 mL round bottom flask, a solution of EXAMPLE 1C (4.25 g, 21.84 mmol), 1,1-di-tert-butoxy-N,N-dimethylmethanamine (28.8 mL, 120 mmol), and N-methyl-2-pyrrolidinone (15 mL) was heated at 85° C. for 2 hours. The reaction was concentrated under high vacuum on a rotavap at 60° C. The residual solid was triturated with 5 mL ether, filtered and dried to provide the title compound. MS (ES r) m/e 249.8 (M+H)+.

出典