反応 #70515

反応方程式

6-(1H-Indol-4-yl)-4-nitro-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole

hydrogen

→

title compound

6-(1H-Indol-4-yl)-2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-4-amine

溶媒

ethylacetate

反応条件

後処理

1. 1
   その他at 30° C.
2. 2
   その他Solvent was removed in vacuo

実験手順

6-(1H-Indol-4-yl)-4-nitro-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole (714 mg, 1.97 mmol) was dissolved in ethylacetate (100 ml) and the compound was hydrogenated using the H-cube™ (available from THALESNano) using 10% Pd/C catalyst at 30° C. and under 30 bar pressure of hydrogen. Solvent was removed in vacuo. The title compound was isolated as an orange/brown solid (629 mg) which was used in subsequent reactions without further purification.

出典