反応 #70512

反応方程式

3-[4-(1H-Indol-3-yl)-piperidine-1-carbonyl]-benzonitrile

NaOH

tetrabutyl ammonium hydroxide

4-fluoro-benzyl bromide

→

3-{4-[1-(4-Fluoro-benzyl)-1H-indol-3-yl]-piperidine-1-carbonyl}-benzonitrile

溶媒

THF

反応条件

後処理

1. 1
   その他The layers are separated
2. 2
   その他the organic solvent is removed under the reduced pressure
3. 3
   その他purified by a silica gel flash column

実験手順

3-[4-(1H-Indol-3-yl)-piperidine-1-carbonyl]-benzonitrile (0.08 g, 0.24 mmol) is dissolved in 2 ml THF, then 2 ml of 50% NaOH, 0.2 ml tetrabutyl ammonium hydroxide (1.0M in MeOH), 4-fluoro-benzyl bromide (0.055 g, 0.29 mmol) are added and the reaction mixture is stirred at RT for 1.5 hours. The layers are separated and the organic solvent is removed under the reduced pressure, purified by a silica gel flash column using heptane and ethyl acetate as the elutes.

出典