反応 #7038

反応方程式

5-fluoroindole

butyraldehyde

→

1,1-di-(5-fluoroindol-3-yl)-butane

収率 45.0%

反応条件

後処理

1. 1
   その他This was prepared in the same way
2. 2
   その他The reaction
3. 3
   温度however, was heated
4. 4
   温度under reflux for 24 hours
5. 5
   その他The end product was isolated
6. 6
   その他purified by chromatography on an SiO2 column

実験手順

This was prepared in the same way as described in example 2/2 starting from 5-fluoroindole and butyraldehyde. The reaction, however, was heated under reflux for 24 hours. The end product was isolated and purified by chromatography on an SiO2 column using a hexane:ethyl ether gradient ranging from 7:3 to 4:6 as the eluent. Yield 45%.

出典