反応 #70373

ord-11966a011f9f4a1faf82dfb6f280c592

反応方程式

C[C@]12CCCCC1C(=C(F)F)C[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC13OCCOC12OCCO3
17,17-bis(ethylendioxy)-6-difluoromethyleneandrostane
C=C1C[C@@H]2[C@H](CC[C@]3(C)C(=O)CC[C@@H]23)[C@@]2(C)CCC(=O)CC12
6-methyleneandrostane-3,17-dione
→
C[C@]12CCC(=O)CC1C(=C(F)F)C[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
title compound
収率 99.0%
C[C@]12CCC(=O)CC1C(=C(F)F)C[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
6-Difluoromethyleneandrostane-3,17-dione
収率 99.0%

反応物

C[C@]12CCCCC1C(=C(F)F)C[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC13OCCOC12OCCO3
17,17-bis(ethylendioxy)-6-difluoromethyleneandrostane
C=C1C[C@@H]2[C@H](CC[C@]3(C)C(=O)CC[C@@H]23)[C@@]2(C)CCC(=O)CC12
6-methyleneandrostane-3,17-dione

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    洗浄The combined organic extracts were washed with H2O
  2. 2
    乾燥dried over Na2SO4
  3. 3
    その他evaporated to dryness

実験手順

The title compound II-ak was prepared in 99% yield from 3,3:17,17-bis(ethylendioxy)-6-difluoromethyleneandrostane by the procedure described above for the preparation of 6-methyleneandrostane-3,17-dione (II-ac, Prepn. 13). The combined organic extracts were washed with H2O, dried over Na2SO4 and evaporated to dryness. 1H-NMR (300 MHz, acetone-d6, ppm from TMS): δ 2.85-0.95 (20H, m), 1.12 (3H, s), 0.88 (3H, s).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08536160B2uspto-grants-2013_09