反応 #70367

反応方程式

6α-formylandrostane-3,17-dione

KMnO4

→

6α-carboxyandrostane-3,17-dione

収率 96.0%

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   その他the mixture was quenched by addition of 40% aqueous NaHSO3 solution
3. 3
   ろ過The suspension was filtered
4. 4
   洗浄washed with H2O
5. 5
   その他the filtrate was freeze-dried
6. 6
   抽出extracted with EtOAc (4×70 mL)
7. 7
   乾燥The combined organic extracts were dried over Na2SO4
8. 8
   その他evaporated to dryness

実験手順

To a stirred suspension of 6α-formylandrostane-3,17-dione (1.77 g) in t-ButOH (35 mL) and 5% aqueous Na2HPO4 solution (21.5 mL), 1N aqueous KMnO4 (35 mL) was added. After 5 minutes at room temperature, the mixture was quenched by addition of 40% aqueous NaHSO3 solution. The suspension was filtered, washed with H2O and the filtrate was freeze-dried. The residue was taken up with H2O (50 mL) and extracted with EtOAc (4×70 mL). The combined organic extracts were dried over Na2SO4 and evaporated to dryness to give 6α-carboxyandrostane-3,17-dione (1.80 g, 96%). 1H-NMR (300 MHz, acetone-d6, ppm from TMS): δ 11.99 (1H, bb), 2.46-0.73 (21H, m), 1.01 (3H, s), 0.79 (3H, s).

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