反応 #70349

反応方程式

residue

Ethyl 2-(6-(2-fluoro-5-methoxyphenyl)-5-methylpyridin-3-ylamino)-5-methylbenzoate

NaOH

→

expected product

収率 67.0%

2-(6-(2-Fluoro-5-methoxyphenyl)-5-methylpyridin-3-ylamino)-5-methylbenzoic acid

収率 67.0%

溶媒

ethanol

water

MeOH NH3

反応条件

後処理

1. 1
   その他the solvent was evaporated
2. 2
   その他the solid obtained
3. 3
   抽出extracted with CHCl3
4. 4
   その他The crude mixture was purified over a SCX cartridge

実験手順

The solid residue obtained in step A was dissolved in 2 ml of ethanol and 0.150 ml of aqueous solution 2N NaOH were added. The mixture was heated at 60° C. for 2 hours, the solvent was evaporated and the solid obtained was suspended in water. The pH was taken to 6.5 and extracted with CHCl3. The crude mixture was purified over a SCX cartridge eluting with MeOH/NH3 10:1 affording 0.030 g (yield 67%) of the expected product.

出典