反応 #70347

反応方程式

residue

tert-butyl 2-(5,6-difluoropyridin-3-ylamino)-5-methylbenzoate

→

expected product

収率 15.0%

2-(5,6-diflouropyridin-3-ylamino)-5-methylbenzoic acid

収率 15.0%

溶媒

trifluoroacetic acid

反応条件

後処理

1. 1
   その他The solvent was evaporated
2. 2
   その他the solid residue was triturated with an isopropyl ether/hexane mixture
3. 3
   ろ過The solid was filtered off

実験手順

The solid residue obtained in step A was dissolved in 0.78 ml of trifluoroacetic acid and stirred for 1 hour at room temperature. The solvent was evaporated and the solid residue was triturated with an isopropyl ether/hexane mixture. The solid was filtered off affording 0.01 g (yield 15%) of the expected product.

出典