反応 #70342

反応方程式

5-methyl-2-(quinolin-3-ylamino)benzoic acid

→

desired compound

収率 79.0%

5-methyl-2-(5,6,7,8-tetrahydroquinolin-3-ylamino)benzoic acid

収率 79.0%

溶媒

TFA

反応条件

後処理

1. 1
   ろ過After that the reaction mixture was filtered
2. 2
   濃縮concentrated
3. 3
   workup.DISSOLUTIONredissolved in water
4. 4
   workup.ADDITIONThe pH was adjusted to 4-5 by addition of 2N NaOH
5. 5
   その他a solid was formed
6. 6
   その他This yellow solid formed

実験手順

A solution of 5-methyl-2-(quinolin-3-ylamino)benzoic acid (Example 16) (1.08 mmol, 0.30 g) in TFA (2.5 ml) was hydrogenated under pressure (58 psi) with PtO2 (0.11 mmol, 0.028 g) as catalyst until all starting material disappeared. After that the reaction mixture was filtered, concentrated and redissolved in water. The pH was adjusted to 4-5 by addition of 2N NaOH and a solid was formed. This yellow solid formed was the desired compound (0.249 mg, 79% of yield).

出典