反応 #70339

反応方程式

residue

Methyl 2-(2-(2-chlorophenyl)pyrimidin-5-ylamino)-5-cyclopropylbenzoate

NaOH

→

expected product

収率 81.0%

2-(2-(2-Chlorophenyl)pyrimidin-5-ylamino)-5-cyclopropylbenzoic acid

収率 81.0%

溶媒

methanol

water

反応条件

後処理

1. 1
   その他the solvent was evaporated
2. 2
   その他the solid obtained
3. 3
   抽出extracted with CHCl3
4. 4
   その他The crude mixture was purified over a SiO2 eluting with DCM/MeOH 2%

実験手順

The solid residue obtained in step A was dissolved in methanol (3 ml) and aqueous solution 2N NaOH (1 ml) was added. The mixture was heated at 60° C. for 2 hours, the solvent was evaporated and the solid obtained was suspended in water. The pH was taken to 6.5 and extracted with CHCl3. The crude mixture was purified over a SiO2 eluting with DCM/MeOH 2% affording 0.170 g (yield 81%) of the expected product.

出典