反応 #70336

反応方程式

tert-butyl 2-(5-fluoro-6-phenylpyridin-3-ylamino)-5-methylbenzoate

→

expected product

2-(5-Fluoro-6-phenylpyridin-3-ylamino)-5-methylbenzoic acid

溶媒

TFA

反応条件

後処理

1. 1
   その他the crude mixture was purified by reverse phase chromatography
2. 2
   その他affording

実験手順

A solution of tert-butyl 2-(5-fluoro-6-phenylpyridin-3-ylamino)-5-methylbenzoate (0.83 mmol, 0.313 g) in TFA (5 ml) was stirred at room temperature for 30 minutes. The solvent was reduced under reduced pressure and the crude mixture was purified by reverse phase chromatography using a 30% to 100% (Water-ACN) gradient and affording 0.119 g (40% of yield) of the expected product.

出典