反応 #70334

反応方程式

methyl 2-(6-(benzyloxy)-5-phenylpyridin-3-ylamino)-5-cyclopropylbenzoate

→

5-Cyclopropyl-2-(6-hydroxy-5-phenylpyridin-3-ylamino)benzoic acid

溶媒

TFA

反応条件

後処理

1. 1
   その他The solvent was removed under reduced pressure
2. 2
   workup.ADDITION2N aqueous NaOH were added
3. 3
   その他The solvent was removed
4. 4
   抽出extracted with CHCl3
5. 5
   その他The crude mixture was purified by ionic exchange through a SCX cartridge
6. 6
   その他affording
7. 7
   その他0.060 g (50% of yield)

実験手順

A solution of methyl 2-(6-(benzyloxy)-5-phenylpyridin-3-ylamino)-5-cyclopropylbenzoate (0.34 mmol, 0.155 g) in TFA (1.3 ml) was stirred at 45° C. for 30 minutes. The solvent was removed under reduced pressure. The crude mixture was solved in ethanol (2 ml), 2N aqueous NaOH were added and stirred at room temperature for 16 hours. The solvent was removed and the crude was neutralised with 2N aqueous HCl and extracted with CHCl3. The crude mixture was purified by ionic exchange through a SCX cartridge affording 0.060 g (50% of yield).

出典