反応 #70333

反応方程式

5-cyclopropyl-2-(5-methyl-6-phenylpyridin-3-ylamino)benzoic acid

mCPBA

→

expected product

5-(2-Carboxy-4-cyclopropylphenylamino)-3-methyl-2-phenylpyridine 1-oxide

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他at 0°
2. 2
   workup.ADDITIONAfter the addition the mixture
3. 3
   その他The solvent was evaporated
4. 4
   その他the solid residue was triturated with a water/ethyl acetate mixture
5. 5
   ろ過The solid was filtered off
6. 6
   その他affording

実験手順

To a stirred solution of 5-cyclopropyl-2-(5-methyl-6-phenylpyridin-3-ylamino)benzoic acid (0.29 mmol, 0.1 g) in 4 ml of dichloromethane was added mCPBA in portions, at 0° and under argon atmosphere. After the addition the mixture was stirred overnight at room temperature. The solvent was evaporated and the solid residue was triturated with a water/ethyl acetate mixture. The solid was filtered off affording 0.035 g (33% of yield) of the expected product.

出典