反応 #7029

反応方程式

1-(Biphenyl-4-carbonyl)-4-(2-fluorophenyl)thiosemicarbazide

hydrochloric acid

→

5-biphenyl-4-yl-4-(2-fluorophenyl)-4H-1,2,4-triazole-3-thiol

収率 97.4%

溶媒

sodium hydroxide

反応条件

後処理

1. 1
   温度refluxed
2. 2
   温度under heating for 3 hours
3. 3
   ろ過The precipitate was filtered
4. 4
   洗浄washed with water

実験手順

1-(Biphenyl-4-carbonyl)-4-(2-fluorophenyl)thiosemicarbazide (12.1 g) was suspended in aqueous 2 mol/liter sodium hydroxide solution (300 ml), and refluxed under heating for 3 hours. After the reaction solution was cooled to ambient temperature, the solution was neutralized under ice cooling with conc. hydrochloric acid. The precipitate was filtered and washed with water, to afford 5-biphenyl-4-yl-4-(2-fluorophenyl)-4H-1,2,4-triazole-3-thiol as pale yellow solid (11.2 g, 97%). The physico-chemical values are as follows.

出典