反応 #70208

反応方程式

3′,4′-Methylenedioxyacetophenone

compound 19

O-(4-Nitrobenzyl)hydroxylamine Hydrochloride

→

CP30255

収率 87.0%

(E)-3′,4′-Methylenedioxyacetophenone O-4-Nitrobenzyl Oxime

収率 87.0%

反応条件

後処理

1. 1
   温度After being heated for 3 h the reaction mixture
2. 2
   温度was cooled
3. 3
   ろ過the resulting solid filtered off
4. 4
   洗浄washed with cold isopropanol (3.0 mL)

実験手順

3′,4′-Methylenedioxyacetophenone (22) (150 mg, 0.914 mmol) was condensed with compound 19 (206 mg, 1.01 mmol) according to the general procedure II-A defined above. After being heated for 3 h the reaction mixture was cooled and the resulting solid filtered off and washed with cold isopropanol (3.0 mL) to afford the title compound CP30255 (250 mg, 87%) as a yellow solid, m.p. 158.7-160.5° C.

出典