反応 #70047

反応方程式

1-(1H-benzo[d]imidazol-5-yl)-5-(4-(4-oxocyclohexyl)phenyl)pyrrolidine-2,4-dione

thionyl chloride

TFA

→

title compound

1-(1H-Benzo[d]imidazol-5-yl)-5-(4-(4-oxocyclohexyl)phenyl)-4-methoxy-1H-pyrrol-2(5H)-one

反応条件

後処理

1. 1
   その他The compound was synthesized
2. 2
   その他The volatiles were evaporated
3. 3
   その他the residue was partitioned between sodium bicarbonate solution and MeOH/CHCl3 (5/95)
4. 4
   洗浄The organic layer was washed with brine
5. 5
   乾燥dried over Na2SO4
6. 6
   その他evaporated
7. 7
   その他The residue was purified by column chromatography

実験手順

The compound was synthesized starting from 1-(1H-benzo[d]imidazol-5-yl)-5-(4-(4-oxocyclohexyl)phenyl)pyrrolidine-2,4-dione (1.5 g, 3.87 mmol) and thionyl chloride (1.1 g, 9.1 mmol) according to method 6 described above. The compound was further treated with TFA (5 ml) at room temperature for 1 h. The volatiles were evaporated and the residue was partitioned between sodium bicarbonate solution and MeOH/CHCl3 (5/95). The organic layer was washed with brine, dried over Na2SO4 and evaporated. The residue was purified by column chromatography to give the title compound.

出典