反応 #69969

反応方程式

Water

methanesulphonyl chloride

1-(4-bromophenyl)piperazine

triethylamine

→

1-(4-Bromophenyl)-4-(methanesulphonyl)piperazine

溶媒

dichloromethane

反応条件

後処理

1. 1
   洗浄the organic phase is washed twice with water
2. 2
   乾燥dried over magnesium sulphate
3. 3
   その他the solvent is evaporated under reduced pressure
4. 4
   その他to result in 26.2 g of 1-(4-bromophenyl)-4-(methanesulphonyl)piperazine
5. 5
   その他as is without other purification

実験手順

7.7 ml of methanesulphonyl chloride are added to a solution of 20 g of 1-(4-bromophenyl)piperazine and 17.34 ml of triethylamine in 394 ml of dichloromethane. The reaction medium is stirred at ambient temperature for 4 h. Water is subsequently added and the organic phase is washed twice with water and dried over magnesium sulphate and then the solvent is evaporated under reduced pressure to result in 26.2 g of 1-(4-bromophenyl)-4-(methanesulphonyl)piperazine. The product is subsequently used as is without other purification.

出典