反応 #699688

反応方程式

pentafluoropyridine

dimethylamine

methylene chloride

→

4-dimethylamino-2,3,5,6-tetrafluoropyridine

溶媒

water

反応条件

後処理

1. 1
   洗浄was washed with water
2. 2
   その他dried over basic alumina
3. 3
   その他The solvent was removed in vacuo

実験手順

To methylene chloride (50 mL) cooled in an ice bath was added pentafluoropyridine (2.0 g, 11.8 mmol) and dimethylamine (2.97 mL of a 40% solution in water, 24 mmol). After stirring for 30 minutes the solution was washed with water, and dried over basic alumina. The solvent was removed in vacuo to give 4-dimethylamino-2,3,5,6-tetrafluoropyridine; NMR (CDCl3) 3.13 (m,6) ppm.

出典