反応 #69955

反応方程式

2-[5-(4-chloro-phenyl)-2-ethyl-thiophen-3-yl]-cyclopent-4-ene-1,3-dione

magnesium iodide

furan

→

4-[5-(4-chloro-phenyl)-2-ethyl-thiophen-3-yl]-10-oxa-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione

反応条件

後処理

1. 1
   その他The crude reaction mixture
2. 2
   その他is purified by flash chromatography

実験手順

To a stirred solution of 2-[5-(4-chloro-phenyl)-2-ethyl-thiophen-3-yl]-cyclopent-4-ene-1,3-dione (248 mg, 0.78 mmol) in furan (3 ml) is added magnesium iodide (44 mg, 0.15 mmol) and the reaction allowed to stir at room temperature for 4 days. The crude reaction mixture is purified by flash chromatography to give 4-[5-(4-chloro-phenyl)-2-ethyl-thiophen-3-yl]-10-oxa-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione as a white solid (180 mg).

出典