反応 #6981

反応方程式

NaBH(OAc)3

N-(3-Amino-2,2-difluoro-propyl)-4-fluoro-3-{[2-(pyridin-2-ylamino)-thiazol-5-ylmethyl]-amino}-benzamide

dihydrofuran

ozone

→

title compound

収率 51.2%

N-(2,2-Difluoro-3-morpholin-4-yl-propyl)-4-fluoro-3-{[2-(pyridin-2-ylamino)-thiazol-5-ylmethyl]-amino}-benzamide

収率 51.2%

溶媒

CH2Cl2

MeOH

反応条件

後処理

1. 1
   その他to remove excess ozone
2. 2
   workup.ADDITIONwere added over a period of 3 h
3. 3
   洗浄washed with sat. NaHCO3
4. 4
   乾燥dried over Na2SO4
5. 5
   濃縮concentrated
6. 6
   その他The residue was purified by flash column chromatography [silica gel, 1% (NH3/MeOH(2M) in EtOAc]

実験手順

A solution of dihydrofuran (35 mg, 0.5 mmol) in MeOH (1.5 mL) was treated with ozone at −78° C. until the solution turned blue. Argon was streamed through the solution to remove excess ozone. The solution was warmed to 0° C., and N-(3-Amino-2,2-difluoro-propyl)-4-fluoro-3-{[2-(pyridin-2-ylamino)-thiazol-5-ylmethyl]-amino}-benzamide (Example 107) (12 mg, 0.027 mmol)) followed by NaBH(OAc)3 (84 mg) were added over a period of 3 h. The mixture was diluted with CH2Cl2, washed with sat. NaHCO3, dried over Na2SO4 and concentrated. The residue was purified by flash column chromatography [silica gel, 1% (NH3/MeOH(2M) in EtOAc] to afford the title compound (7 mg, 51%) as a white solid. LC/MS; (M+H)+=507. 1HNMR (CD3OD): δ 2.47 (m, 4H); 2.66 (t, 2H, J=13.7 Hz); 3.53 (m, 4H); 3.80 (t, 2H, J=14.3 Hz); 4.48 (s, 2H); 6.78 (m, 1H); 6.86 (d, 1H, J=8.25 Hz); 7.0 (m, 2H); 7.15 (s, 1H); 7.23 (m, 1H); 7.54 (m, 1H), 8.15 (d, 1H, J=4.4 Hz).

出典