反応 #69788

反応方程式

2-(2-bromoethoxy)tetrahydro-2H-pyran

4-iodopyrazole

cesium carbonate

→

4-Iodo-1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-pyrazole

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他In a 1 L 3-neck flask equipped with magnetic stir bar
2. 2
   ろ過Filter the reaction mixture through CELITE®
3. 3
   洗浄wash the filter cake with ACN
4. 4
   濃縮concentrate the filtrate to a golden oil
5. 5
   その他Use without further purification

実験手順

In a 1 L 3-neck flask equipped with magnetic stir bar, nitrogen blanket and internal temperature probe dissolve 2-(2-bromoethoxy)tetrahydro-2H-pyran (34 g, 156 mmol) in acetonitrile (ACN, 400 mL). Add 4-iodopyrazole (29.34 g, 149.74 mmol) followed by cesium carbonate (73.4 g, 223.02 mmol). Stir the mixture at RT for 18 hours. Filter the reaction mixture through CELITE®, wash the filter cake with ACN and concentrate the filtrate to a golden oil. Use without further purification. Yield: 47.819 g (99%). MS (ES) m/z 323 [M+1]+.

出典