反応 #69687

反応方程式

3-hydroxyphthalic anhydride

2,4-dimethoxybenzylamine

acetic acid

→

title compound

収率 73.0%

4-Hydroxy-2-(2,4-dimethoxy-benzyl)-isoindole-1,3-dione

収率 73.0%

溶媒

water

反応条件

後処理

1. 1
   温度to cool
2. 2
   ろ過The white solid was collected by filtration
3. 3
   洗浄washed well with water
4. 4
   その他dried

実験手順

A mixture of 3-hydroxyphthalic anhydride (1.24 g, 7.6 mmol), 2,4-dimethoxybenzylamine (1.14 mL, 7.6 mmol) and acetic acid (5 mL) was heated at 80° C. for 24 hours. The mixture was allowed to cool and diluted with water (20 mL). The white solid was collected by filtration, washed well with water and dried to give the title compound (1.73 g, 73%). 1H NMR (DMSO-d6) 11.00 (1H, s), 7.62 (1H, dd), 7.29 (1H, d), 7.21 (1H, d), 6.90 (1H, d), 6.56 (1H, d), 6.43 (1H, dd), 4.59 (2H, s), 3.79 (3H, s), 3.72 (3H, s). MS: [M−H+] 314.

出典