反応 #696703

反応方程式

4-Vinylbenzyl chloride

Ethyl acetoacetate

sodium ethoxide

→

ethyl 2-(4-vinylbenzyl)-3-oxobutanoate

収率 95.0%

溶媒

ethanol

反応条件

後処理

1. 1
   温度was cooled in an ice-water bath
2. 2
   温度The mixture was refluxed for 16 hours
3. 3
   ろ過the resulting slurry was filtered
4. 4
   その他to remove any salt
5. 5
   その他the solution collected
6. 6
   その他The solvent was removed under reduced pressure

実験手順

Ethyl acetoacetate (27.61 g, 0.21 mol) was dissolved in ethanol (100 ml) which was cooled in an ice-water bath, and sodium ethoxide (15.59 g, 0.22 mol) was added. 4-Vinylbenzyl chloride (33.92 g, 0.2 mole) was added. The mixture was refluxed for 16 hours, then the resulting slurry was filtered to remove any salt, and the solution collected. The solvent was removed under reduced pressure to give ethyl 2-(4-vinylbenzyl)-3-oxobutanoate in the form of a light red liquid (49 g) in 95% yield.

出典